5-Fluorouracil induces autophagic degeneration in rat oral keratinocytes.


In this study, we investigated the effect of 5-fluorouracil (5-FU) on the keratinocytes of oral epithelium. Female Lewis rats were given 5-FU i.v. and were killed 12, 24 or 36 h after injection. The buccal mucosa was dissected. The number of nuclei with DNA strand breaks and the total number of nuclei per volume of the epithelial basal cell layer was… (More)


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@article{Bltzingslwen20015FluorouracilIA, title={5-Fluorouracil induces autophagic degeneration in rat oral keratinocytes.}, author={Inger von B{\"u}ltzingsl{\"o}wen and Mats Jontell and Peter R Hurst and Ulf Nannmark and Tam{\'a}s Kardos}, journal={Oral oncology}, year={2001}, volume={37 6}, pages={537-44} }