5-Fluorouracil-induced apoptosis in cultured oral cancer cells.

@article{Tong20005FluorouracilinducedAI,
  title={5-Fluorouracil-induced apoptosis in cultured oral cancer cells.},
  author={D C Tong and Martin Poot and Ding Hu and Dolphine Oda},
  journal={Oral oncology},
  year={2000},
  volume={36 2},
  pages={
          236-41
        }
}
View on PubMed
doi.org
35 Citations
Background Citations
10
Results Citations
1

35 Citations

Citation Type

Citation Type

5‐Fluorouracil Mediates Apoptosis and G1/S Arrest in Laryngeal Squamous Cell Carcinoma via a p53‐Independent Pathway
TLDR
The results suggest that 5-FU mediates apoptosis and G1/S cell cycle phase arrest in laryngeal carcinoma via a p53-independent but p21WAF1/CIP1-dependent or p21 wAF1-RB-Rb-dependent pathway.
Artemisinin: an alternative treatment for oral squamous cell carcinoma.
TLDR
The results indicate that AR is cytotoxic to transformed oral epithelial cells through apoptosis, while 5-FU is cytOToxic primarily through cell toxicity.
Apoptosis-inducing activity and tumor-specificity of antitumor agents against oral squamous cell carcinoma
5-Fluorouracil induces autophagic degeneration in rat oral keratinocytes.
Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents
TLDR
The findings suggest that enhanced Bax expression may have therapeutic application in enhancing the efficacy of chemotherapy in pancreatic cancers.
Induction of apoptosis in oral cancer cells: agents and mechanisms for potential therapy and prevention.
Scutellariae radix induces apoptosis in chemoresistant SCC-25 human tongue squamous carcinoma cells.
TLDR
The anticancer activity of Scutellariae radix in chemoresistant SCC-25 oral squamous carcinoma cells was highlighted, due to decreased cell proliferation, changes in cell morphology, and the activation of caspase and MAPK pathways.
Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines
TLDR
Tualang honey showed antiproliferative effect on OSCC and HOS cell lines by inducing early apoptosis by inducing time and dose dependent inhibitory effect of honey.
Pseudomonas aeruginosa Exotoxin A Reduces Chemoresistance of Oral Squamous Carcinoma Cell via Inhibition of Heat Shock Proteins 70 (HSP70)
TLDR
Results indicate that PEA reduced the chemoresistance through inhibition of HSP70 expression and also induced apoptosis in chemoresistant YD-9 cells.
Pseudomonas aeruginosa Exotoxin A Induces Apoptosis in Chemoresistant YD-9 Human Oral Squamous Carcinoma Cell Line Via Accumulation of p53 and Activation of Caspases
TLDR
It was demonstrated here that Pseudomonas aeruginosa exotoxin A (PEA) significantly decreased the viability of chemoresistant YD-9 cells in the apoptosis mechanism.
...
1
2
3
4
...

References

SHOWING 1-10 OF 22 REFERENCES
Chemotherapy‐Induced Apoptosis in Epithelial Ovarian Cancers
5-Fluorouracil induces apoptotic cell death with G2 phase arrest in human breast cancer grafted in nude mice.
Treatment with 5-fluorouracil and its derivatives causes DNA double strand breaks in the S phase, and the subsequent cell death. A 5-Fluorouracil derivative (UFT), that is converted to 5-fluorouracil…
5-FU-induced apoptosis correlates with efficacy against human gastric and colon cancer xenografts in nude mice.
TLDR
It is reported here that apoptosis is a key event in the killing of human tumor cells by 5-fluorouracil (5-FU) in vivo, and inhibition of DNA synthesis induced by 7-FU are closely associated with its antitumor effect.
Features of apoptotic cells measured by flow cytometry.
The present review describes several methods to characterize and differentiate between two different mechanisms of cell death, apoptosis and necrosis. Most of these methods were applied to studies of…
The effects of 5-fluorouracil and mitomycin C on the corneal endothelium.
TLDR
It is concluded that with respect to the clinically used concentrations and methods of application of 5-FU and MMC in vivo endothelial toxicity is not to be expected, however, in cases of accidental access of MMC to the anterior eye chamber and following a reduction of aqueous turnover rate the safety of M MC is unwarranted.
Detection of apoptosis in live cells by MitoTracker red CMXRos and SYTO dye flow cytometry.
TLDR
It is concluded that changes in nucleic acid stability or conformation may vary during apoptosis from one cell type to another, but mitochondrial demise may be common to all apoptotic pathways.
Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis).
TLDR
Flow cytometry appears to be the methodology of choice to study various aspects of necrobiology and it is expected that flow cytometry will be the dominant methodology for necro biology.
Programmed Cell Death in Tumours and Tissues
Chemotherapy in head and neck cancer.
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
  • T. Mosmann
  • Biology
    Journal of immunological methods
  • 1983
...
1
2
3
...