5-Fluorouracil chemotherapy upregulates cytokines and alters hippocampal dendritic complexity in aged mice.

@article{Groves20175FluorouracilCU,
  title={5-Fluorouracil chemotherapy upregulates cytokines and alters hippocampal dendritic complexity in aged mice.},
  author={Thomas R Groves and Ryan A Farris and Julie M E Anderson and Tyler C Alexander and Frederico Kiffer and Gwendolyn Carter and Jing Wang and Marjan Boerma and Anti{\~n}o R. Allen},
  journal={Behavioural brain research},
  year={2017},
  volume={316},
  pages={215-224}
}
5-Fluorouracil (5-Fu) is commonly used chemotherapy drug, but it can lead to the impairment of cognitive function. The pathogenesis of this injury is unknown but may involve modifications to dendritic structure and/or alterations in dendritic spine density and morphology. Dendritic spines are sites of excitatory synaptic transmission and changes in spine structure and dendrite morphology are thought to represent a morphological correlate of altered brain functions associated with hippocampal… CONTINUE READING
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