5-Fluorouracil and methotrexate administered simultaneously as a continuous infusion. A phase I study.

@article{Lokich19855FluorouracilAM,
  title={5-Fluorouracil and methotrexate administered simultaneously as a continuous infusion. A phase I study.},
  author={Jacob J. Lokich and David B. Phillips and Ralph Green and Stacey Paul and H. -H. Sonneborn and T E Zipoli and Gregory A. Curt},
  journal={Cancer},
  year={1985},
  volume={56 10},
  pages={2395-8}
}
Infusion delivery systems have been evaluated for administration of many individual chemotherapeutic agents including 5-fluorouracil (5-FU) and methotrexate (MTX). This study combined the two drugs as an admixture, and in a Phase I trial design established a useful dose schedule for each of the component drugs. 5-FU at a fixed dose rate of 300 mg/M2/day was delivered with methotrexate (MTX) at four different dose rates (0.75, 1.0, 1.5, or 2.0 mg/M2/day, respectively). The drug solution was… CONTINUE READING