5-Fluoropyrimidin-2-one, a new metaphase arresting agent.

@article{Oftebro19725Fluoropyrimidin2oneAN,
  title={5-Fluoropyrimidin-2-one, a new metaphase arresting agent.},
  author={R. Oftebro and O. Grimmer and T. B. Oyen and S. Laland},
  journal={Biochemical pharmacology},
  year={1972},
  volume={21 18},
  pages={
          2451-6
        }
}
Abstract 5-Fluoropyrimidin-2-one arrests reversibly the Chang strain of human liver cells in the metaphase. The effect is dependent on the presence of the halogen in the molecule and seems to be due to the substance per se. 
A new purine analogue with antimitotic activity.
TLDR
The compound 4-benzylamino 6-methyl 7-benzyl pyrrolo [2,3-d] pyrimidine has been found to arrest cultured cells in metaphase and some irreversible effects occur, such as anarchic reconstruction of the nuclear membrane around dispersed chromosomes and formation of multinucleated giant cells. Expand
Metahalones, a new class of metaphase inhibitors
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The results suggest that the metaphase-inhibitory activity is associated with the 2-0~0 group and the 5-halogen, and that certain substituents in other positions are permissable for the retainment of activity. Expand
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TLDR
The binding of NY 4137 to tubulin at or near the colchicine binding site may be responsible for the metaphase arrest. Expand
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  • Chemistry, Medicine
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  • 1987
TLDR
The pyrimidinone moiety may be considered as an important pharmacophore for incorporation in the design of molecules of biological interest in view of the diverse types of biological activities associated with p Skyrimidinones and molecules having pyrimidine as a component substructure. Expand
Resistance to the mitotic inhibitor NY 3170 in Chinese hamster ovary cells.
TLDR
This work has isolated CHO cells which are resistant to NY 3170, a member of the metahalone group of antimitotic drugs, and found that other mutants, selected on the basis of vincristine resistance, are cross-resistant to New York 3170. Expand
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