5-Fluorocytosine antagonizes the action of sterol biosynthesis inhibitors in Candida glabrata.

@article{Siau19995FluorocytosineAT,
  title={5-Fluorocytosine antagonizes the action of sterol biosynthesis inhibitors in Candida glabrata.},
  author={H Siau and David Kerridge},
  journal={The Journal of antimicrobial chemotherapy},
  year={1999},
  volume={43 6},
  pages={
          767-75
        }
}
  • H. Siau, D. Kerridge
  • Published 1999
  • Biology, Medicine
  • The Journal of antimicrobial chemotherapy
The concentration-dependent antagonistic interaction between 5-fluorocytosine and a sterol biosynthesis inhibitor (SBI) was studied using intact cells and cell-free extracts of Candida glabrata. 5-Fluorocytosine promoted incorporation of radioactivity into 4-desmethylsterols (P < 0.01), and enhanced the relative and absolute increases of ergosterol (P < 0.05) in C. glabrata incubated aerobically with an SBI (miconazole or amorolfine). Further aerobic incubation of C. glabrata with combinations… Expand
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