5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.

@article{Su20095Fluoro2indolylD,
  title={5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.},
  author={Wenjuan Su and Oladapo O. Yeku and Srinivas Olepu and Alyssa Genna and Jae-Sook Park and Hongmei Ren and Guangwei Du and Michael H. Gelb and Andrew J. Morris and Michael A. Frohman},
  journal={Molecular pharmacology},
  year={2009},
  volume={75 3},
  pages={437-46}
}
The signaling enzyme phospholipase D (PLD) and the lipid second messenger it generates, phosphatidic acid (PA), are implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. PLD production of PA is inhibited by the primary alcohol 1-butanol, which has thus been widely employed to identify PLD/PA-driven processes. However, 1-butanol does not always effectively reduce PA accumulation, and its use… CONTINUE READING
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