5-FU multifocal inflammatory leukoencephalopathy and dihydropyrimidine dehydrogenase deficiency.

@article{Franco20015FUMI,
  title={5-FU multifocal inflammatory leukoencephalopathy and dihydropyrimidine dehydrogenase deficiency.},
  author={Domingo Franco and Harry S. Greenberg},
  journal={Neurology},
  year={2001},
  volume={56 1},
  pages={110-2}
}
Multifocal inflammatory leukoencephalopathy (MIL) is a cerebral demyelinating syndrome that develops after chemotherapy with 5-fluorouracil (5-FU) and levamisole. The authors report a patient who developed MIL after 5-FU administration not in association with levamisole. She was subsequently diagnosed with partial deficiency of dihydropyrimidine dehydrogenase, an enzyme necessary for 5-FU catabolism. The authors suggest that MIL is a direct result of 5-FU chemotherapy and that patients with… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-8 of 8 references

Neurotoxicity of 5 - fluorouracil and levamisole

  • JB Posner
  • Neurology Network Commentary
  • 1997

Similar Papers

Loading similar papers…