5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells.

@article{Senkiv20165Ene4thiazolidinonesIA,
  title={5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells.},
  author={Julia Senkiv and Nataliya Finiuk and Danylo Kaminskyy and Dmytro Havrylyuk and Magdalena N Wojtyra and Iryna J Kril and Andrzej K. Gzella and Rostyslav S. Stoika and Roman Lesyk},
  journal={European journal of medicinal chemistry},
  year={2016},
  volume={117},
  pages={33-46}
}
The article presents the synthesis of 5-ene-4-thiazolidinone derivatives with pyrazole core linked by enamine group. The structure and purity of compounds were confirmed by analytical and spectral data including X-ray analysis. Target compounds were screened for their anticancer activity and selective antileukemic action was confirmed. 5-[5-(2-Hydroxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-ylmethylene]-3-(3-acetoxyphenyl)-2-thioxothiazolidin-4-one (compound 1) was selected as most active agent… CONTINUE READING
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