5-En-androstene-3 beta,17 beta-diol inhibits the growth of MCF-7 breast cancer cells when oestrogen receptors are blocked by oestradiol.

@article{Boccuzzi19945Enandrostene3BB,
  title={5-En-androstene-3 beta,17 beta-diol inhibits the growth of MCF-7 breast cancer cells when oestrogen receptors are blocked by oestradiol.},
  author={G. Boccuzzi and E. Brignardello and M. Di Monaco and V. Gatto and L. Leonardi and A. Pizzini and M. Gallo},
  journal={British Journal of Cancer},
  year={1994},
  volume={70},
  pages={1035 - 1039}
}
Adrenal androgens show a dual and apparently opposite effect on the growth of oestrogen-responsive breast cancer: they stimulate growth on their own, but counteract the growth-stimulatory effect of oestrogens. Focusing on the inhibitory action we have studied the effects of 5-en-androstene-3 beta,17 beta-diol (ADIOL) on the growth of oestrogen-responsive MCF-7 breast cancer cells in the presence of oestrogens (oestradiol and diethylstilboestrol), antiestrogens (tamoxifen) and antiandrogens… Expand
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