5-Benzylidenethiazolidin-4-ones as multitarget inhibitors of bacterial Mur ligases.

  title={5-Benzylidenethiazolidin-4-ones as multitarget inhibitors of bacterial Mur ligases.},
  author={Tihomir Toma{\vs}i{\vc} and Nace Zidar and Andreja Bujan Kovac and Samo Turk and M. Simcic and Didier Blanot and Manica Mueller-Premru and Metka Filipi{\vc} and Simona Golic Grdadolnik and Anamarija Zega and Marko Anderluh and Stanislav Gobec and Danijel Kikelj and Luc{\'i}ja Peterlin Ma{\vs}i{\vc}},
  volume={5 2},
Mur ligases participate in the intracellular path of bacterial peptidoglycan biosynthesis and constitute attractive, although so far underexploited, targets for antibacterial drug discovery. A series of hydroxy-substituted 5-benzylidenethiazolidin-4-ones were synthesized and tested as inhibitors of Mur ligases. The most potent compound 5 a was active against MurD-F with IC(50) values between 2 and 6 microm, making it a promising multitarget inhibitor of Mur ligases. Antibacterial activity… CONTINUE READING

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