5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line.

  title={5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line.},
  author={Valentina Zuliani and Caterina Carmi and Mirko Rivara and Marco Fantini and Alessio Lodola and Federica Vacondio and Fabrizio Bordi and Pier Vincenzo Plazzi and Andrea Cavazzoni and Maricla Galetti and Roberta Alfieri and Pier Giorgio Petronini and Marco Mor},
  journal={European journal of medicinal chemistry},
  volume={44 9},
Benzylidene hydantoins have been recently reported as a new class of EGFR inhibitors. We describe here a simple and efficient methodology for the parallel solution-phase synthesis of a library of 5-benzylidene hydantoins, which were evaluated for antiproliferative activity on the human lung adenocarcinoma A549 cell line. Various substituents at positions 1, 3 and 5 on the hydantoin nucleus were examined. In the presence of a 5-benzylidene group and of a lipophilic substituent at position 1… CONTINUE READING


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