5-Azacytidine inhibits the lpr gene-induced lymphadenopathy and acceleration of lupus-like syndrome in MRL/MpJ-lpr/lpr mice.

@article{Yoshida19905AzacytidineIT,
  title={5-Azacytidine inhibits the lpr gene-induced lymphadenopathy and acceleration of lupus-like syndrome in MRL/MpJ-lpr/lpr mice.},
  author={Hisahiro Yoshida and Masaru Yoshida and Ram{\'o}n Merino and Toshio Shibata and Shozo Izui},
  journal={European journal of immunology},
  year={1990},
  volume={20 9},
  pages={1989-93}
}
MRL/MpJ-lpr/lpr mice spontaneously develop a lupus-like autoimmune disorder characterized by massive proliferation of T cells and rapidly fatal immune complex glomerulonephritis. We evaluated the therapeutic effect of 5-azacytidine (5AC), a cytidine analogue known as an inhibitor of DNA methylation, in MRL/MpJ-lpr/lpr mice. Intraperitoneal injection of 5AC… CONTINUE READING