5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1.

@article{Dapp20095AzacytidineCI,
  title={5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1.},
  author={Michael J Dapp and Christine L. Clouser and Steven E. Patterson and Louis M Mansky},
  journal={Journal of virology},
  year={2009},
  volume={83 22},
  pages={11950-8}
}
Ribonucleosides inhibit human immunodeficiency virus type 1 (HIV-1) replication by mechanisms that have not been fully elucidated. Here, we report the antiviral mechanism for the ribonucleoside analog 5-azacytidine (5-AZC). We hypothesized that the anti-HIV-1 activity of 5-AZC was due to an increase in the HIV-1 mutation rate following its incorporation… CONTINUE READING