5-Azacytidine Improves the Osteogenic Differentiation Potential of Aged Human Adipose-Derived Mesenchymal Stem Cells by DNA Demethylation

@inproceedings{Yan20145AzacytidineIT,
  title={5-Azacytidine Improves the Osteogenic Differentiation Potential of Aged Human Adipose-Derived Mesenchymal Stem Cells by DNA Demethylation},
  author={Xueying Yan and Sabrina Ehnert and Mihaela Culmes and Anastasia Bachmann and Claudine Seeliger and Lilianna Schyschka and Zhiyong Wang and Afshin Rahmanian-Schwarz and U. St{\"o}ckle and P A De Sousa and Jaroslav Pelisek and Andreas K Nussler},
  booktitle={PloS one},
  year={2014}
}
The therapeutic value of adipose-derived mesenchymal stem cells (Ad-MSCs) for bone regeneration is critically discussed. A possible reason for reduced osteogenic potential may be an age-related deterioration of the Ad-MSCs. In long term in vitro culture, epigenomic changes in DNA methylation are known to cause gene silencing, affecting stem cell growth as well as the differentiation potential. In this study, we observed an age-related decline in proliferation of primary human Ad-MSCs. Decreased… CONTINUE READING

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Epigenetics: Judge, jury and executioner of stem cell fate

  • J Tollervey, VV Lunyak
  • Epigenetics
  • 2012
Highly Influential
3 Excerpts

Role of Tet proteins in 5 mC to 5 hmC conversion, ES-cell self-renewal and inner cell mass

  • S Ito, AC D’Alessio, OV Taranova, K Hong, LC Sowers
  • 2010
Highly Influential
4 Excerpts

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