5-Aza-2′-deoxycytidine Leads to Reduced Embryo Implantation and Reduced Expression of DNA Methyltransferases and Essential Endometrial Genes

@inproceedings{Ding20125Aza2deoxycytidineLT,
  title={5-Aza-2′-deoxycytidine Leads to Reduced Embryo Implantation and Reduced Expression of DNA Methyltransferases and Essential Endometrial Genes},
  author={Yubin Ding and Chun-lan Long and Xue-qing Liu and Chen Xuemei and Liang-Rui Guo and Yin-yin Xia and Jun-lin He and Ying-xiong Wang},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND The DNA demethylating agent 5-aza-2'-deoxycytidine (5-aza-CdR) incorporates into DNA and decreases DNA methylation, sparking interest in its use as a potential therapeutic agent. We aimed to determine the effects of maternal 5-aza-CdR treatment on embryo implantation in the mouse and to evaluate whether these effects are associated with decreased levels of DNA methyltransferases (Dnmts) and three genes (estrogen receptor α [Esr1], progesterone receptor [Pgr], and homeobox A10 [Hoxa10… CONTINUE READING
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