5-Aza-2'-deoxycytidine: cell differentiation and DNA methylation.

  title={5-Aza-2'-deoxycytidine: cell differentiation and DNA methylation.},
  author={Shirley M. Taylor},
  volume={7 Suppl 1},
5-Azacytidine (5-aza-CR) and 5-aza-2'-deoxycytidine (5-aza-CdR), analogs of cytidine modified in position 5, were originally developed as antitumor agents, and have been useful in the treatment of both childhood and adult leukemias. These agents are cytotoxic per se, but also induce differentiation in several experimental systems, most notably the induction of muscle, adipocytes, and chondrocytes in cultures of drug-treated mouse embryo fibroblasts. The mechanisms underlying this drug-induced… CONTINUE READING