5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer.

@article{Baan20125AminosalicylicAI,
  title={5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer.},
  author={Bart Baan and Ashwin A. Dihal and Eva Hoff and Carina L. Bos and Philip W Voorneveld and Pim J. Koelink and Manon E. Wildenberg and Vanesa Muncan and Jarom Heijmans and Hein W. Verspaget and Dick J. Richel and James C.H. Hardwick and Daniel W. Hommes and Maikel P Peppelenbosch and Gijs van den Brink},
  journal={Gut},
  year={2012},
  volume={61 12},
  pages={1708-15}
}
BACKGROUND 5-Aminosalicylic acid (5-ASA) may protect against the development of inflammation-associated colorectal cancer. In vitro data suggest that, in colorectal cancer cells, 5-ASA induces cell cycle arrest, but the molecular mechanism leading to this arrest remains to be determined. AIM To dissect the signal transduction events that lead to 5-ASA… CONTINUE READING