5-Aminosalicylic Acid Is Not Protective Against Colorectal Cancer in Inflammatory Bowel Disease: A Meta-Analysis of Non-Referral Populations

@article{Nguyen20125AminosalicylicAI,
  title={5-Aminosalicylic Acid Is Not Protective Against Colorectal Cancer in Inflammatory Bowel Disease: A Meta-Analysis of Non-Referral Populations},
  author={Geoffrey C Nguyen and Aliya F. Gulamhusein and Charles N Bernstein},
  journal={The American Journal of Gastroenterology},
  year={2012},
  volume={107},
  pages={1298-1304}
}
OBJECTIVES:Some studies have demonstrated that 5-aminosalicylic acid (5-ASA) is associated with a reduced risk of colorectal cancer (CRC) in inflammatory bowel disease (IBD). However, more recent population-based studies suggest no protective association. We conducted a systematic review that focused on non-referral studies to reassess the role of 5-ASA for this indication.METHODS:We searched MEDLINE, EMBASE, and the Cochrane databases for studies of non-referral populations that assessed the… CONTINUE READING
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