5-Aminolevulinate synthase and the first step of heme biosynthesis.


5-Aminolevulinate synthase catalyzes the condensation of glycine and succinyl-CoA to yield 5-aminolevulinate. In animals, fungi, and some bacteria, 5-aminolevulinate synthase is the first enzyme of the heme biosynthetic pathway. Mutations on the human erythroid 5-aminolevulinate synthase, which is localized on the X-chromosome, have been associated with X… (More)


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@article{Ferreira19955AminolevulinateSA, title={5-Aminolevulinate synthase and the first step of heme biosynthesis.}, author={Germano Ferreira and J. Gong}, journal={Journal of bioenergetics and biomembranes}, year={1995}, volume={27 2}, pages={151-9} }