5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via ERK-dependent HuR binding to an AU-rich element.

Abstract

OBJECTIVE 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) has pleiotropic and beneficial effects on metabolic disorders. However, the effects of AICAR on low density lipoprotein (LDL) metabolism are poorly understood. METHODS AND RESULTS AICAR induces increased LDLR mRNA levels and increased LDLR protein production in hepatocytes. The AICAR… (More)
DOI: 10.1016/j.atherosclerosis.2012.09.033

Topics

5 Figures and Tables

Cite this paper

@article{Yashiro20135Aminoimidazole4carboxamideRS, title={5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via ERK-dependent HuR binding to an AU-rich element.}, author={Takuya Yashiro and Manami Nanmoku and Makoto Shimizu and Jun Inoue and Ryuichiro Sato}, journal={Atherosclerosis}, year={2013}, volume={226 1}, pages={95-101} }