5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-α]pyridine-8-carboxamide (CJ-033,466), a Novel and Selective 5-Hydroxytryptamine4 Receptor Partial Agonist: Pharmacological Profile in Vitro and Gastroprokinetic Effect in Conscious Dogs

@article{Mikami20085Amino6chloroN1isobutylpiperidin4yl,
  title={5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-$\alpha$]pyridine-8-carboxamide (CJ-033,466), a Novel and Selective 5-Hydroxytryptamine4 Receptor Partial Agonist: Pharmacological Profile in Vitro and Gastroprokinetic Effect in Conscious Dogs},
  author={Tadayoshi Mikami and Yasuo Ochi and Keiko Suzuki and Toshiyuki Saito and Yutaka Sugie and Minoru Sakakibara},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2008},
  volume={325},
  pages={190 - 199}
}
5-Hydroxytryptamine (5-HT) receptors and dopamine2 (D2) receptor modulate gastrointestinal motility. Gastroprokinetic agents that act on several 5-HT receptor subtypes and/or D2 receptors are used clinically. Although the 5-HT4 receptor is known to mediate the gastroprokinetic effects of these agents, the absence of highly selective 5-HT4 receptor agonists has made it difficult to confirm the physiological consequences of selective 5-HT4 receptor stimulation. In this study, we report the in… 

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