5-Alpha reductase deficiency: a 40-year retrospective review

@article{Okeigwe20145AlphaRD,
  title={5-Alpha reductase deficiency: a 40-year retrospective review},
  author={Ijeoma Okeigwe and Wendy Kuohung},
  journal={Current Opinion in Endocrinology \& Diabetes and Obesity},
  year={2014},
  volume={21},
  pages={483–487}
}
  • I. OkeigweW. Kuohung
  • Published 1 December 2014
  • Biology
  • Current Opinion in Endocrinology & Diabetes and Obesity
Purpose of review5-Alpha reductase is an enzyme responsible for the conversion of testosterone to dihydrotestosterone. This key enzyme is responsible for triggering masculinization of the male external genitalia. Discovery of 5-alpha reductase deficiency as a syndrome of disordered male sexual development led to our molecular understanding of the role that this key enzyme plays in male sexual differentiation. This article will review the clinical and molecular history behind the discovery of 5… 

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