5-ASA colonic mucosal concentrations resulting from different pharmaceutical formulations in ulcerative colitis.

@article{Dinc20135ASACM,
  title={5-ASA colonic mucosal concentrations resulting from different pharmaceutical formulations in ulcerative colitis.},
  author={Renata D'inc{\'a} and Martina Paccagnella and Romilda Cardin and Surajit Pathak and Vincenzo Baldo and Maria Cecilia Giron and Giacomo carlo Sturniolo},
  journal={World journal of gastroenterology},
  year={2013},
  volume={19 34},
  pages={
          5665-70
        }
}
AIM To compare the mucosal concentrations of 5-aminosalicylic acid (5-ASA) resulting from different pharmaceutical formulations and analyse the influence of inflammation on the mucosal concentrations. METHODS The study included 130 inflammatory bowel disease (IBD) patients receiving 5-ASA as pH-dependent-release formulations (73 patients), time-dependent-release formulations (11 patients), or pro-drugs (18 patients). In addition, 28 patients were receiving topical treatment (2-4 g/d) with pH… CONTINUE READING

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