5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma.

  title={5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma.},
  author={Isabelle Coupienne and Gr{\'e}gory Fettweis and Noem{\'i} Rubio and Patrizia Agostinis and Jacques Piette},
  journal={Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology},
  volume={10 12},
Glioblastoma constitute the most frequent and deadliest brain tumors of astrocytic origin. They are resistant to all current therapies and are associated with a high rate of recurrence. Glioblastoma were previously shown to respond to treatments by 5-aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) mainly by activating a necrotic type of cell death. The receptor-interacting protein 3 (RIP3) has recently been outlined as a key mediator of this caspase-independent form of programmed… CONTINUE READING