5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structure-activity relationship studies on the central 1,3-dioxoperhydropyrido[1,2-c]pyrimidine scaffold.

@article{BartolomNebreda20015Tryptophylamino13dioxoper,
  title={5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structure-activity relationship studies on the central 1,3-dioxoperhydropyrido[1,2-c]pyrimidine scaffold.},
  author={J. Bartolom{\'e}-Nebreda and M. Garc{\'i}a-L{\'o}pez and R. Gonz{\'a}lez-Mu{\~n}iz and E. Cenarruzabeitia and M. Latorre and J. del R{\'i}o and R. Herranz},
  journal={Journal of medicinal chemistry},
  year={2001},
  volume={44 24},
  pages={
          4196-206
        }
}
To further define the pharmacophore of the potent and selective 5-(tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based CCK(1) receptor antagonists the electronic and topographic properties of the central 1,3-dioxoperhydro-pyrido[1,2-c]pyrimidine scaffold have been modified. With this aim, the 1- and 3-oxo groups have been replaced by the thioxo- and deoxi-analogues, and the fused piperidine ring has been contracted to the corresponding pyrrolidine moiety. The results of the… Expand
Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines.
Cholecystokinin antagonists: Pharmacological and therapeutic potential
  • R. Herranz
  • Biology, Medicine
  • Medicinal research reviews
  • 2003
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