5-(Pyrrolidin-2-yl)tetrazole-catalyzed aldol and mannich reactions: acceleration and lower catalyst loading in a continuous-flow reactor.

@article{Odedra20095Pyrrolidin2yltetrazolecatalyzedAA,
  title={5-(Pyrrolidin-2-yl)tetrazole-catalyzed aldol and mannich reactions: acceleration and lower catalyst loading in a continuous-flow reactor.},
  author={Arjan Odedra and Peter H. Seeberger},
  journal={Angewandte Chemie},
  year={2009},
  volume={48 15},
  pages={
          2699-702
        }
}
Continuous organocatalysis: Fast aldol and Mannich reactions require less catalyst when conducted in a microreactor. A proline tetrazole derivative (5-10 mol %) catalyzes asymmetric aldol reactions between various aromatic aldehydes and ketones in microreactor at 60 degrees C with reaction times ranging from 10 to 30 min. 
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