5 , 6 = Dichloro - 1 - # ? - D - ribofuranosylbenzimidazole Inhibits Transcription Elongation by RNA Polymerase I 1 in Vitro


The purine nucleoside analog 5,6-dichloro-l-j3-~-ribofuranosylbenzimidazole (DRB) is a selective inhibitor of transcription by RNA polymerase 11. Although a wealth of in vivo studies have suggested that DRB inhibits transcription by enhancing the premature termination of elongating polymerase molecules, in vitro studies to date have been interpreted to… (More)


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