5'AMP-activated protein kinase activity is increased in adipose tissue of northern elephant seal pups during prolonged fasting-induced insulin resistance.

@article{Viscarra20115AMPactivatedPK,
  title={5'AMP-activated protein kinase activity is increased in adipose tissue of northern elephant seal pups during prolonged fasting-induced insulin resistance.},
  author={Jose A Viscarra and Cory D. Champagne and Daniel E Crocker and Rudy M Ortiz},
  journal={The Journal of endocrinology},
  year={2011},
  volume={209 3},
  pages={317-25}
}
Northern elephant seals endure a 2- to 3-month fast characterized by sustained hyperglycemia, hypoinsulinemia, and increased plasma cortisol and free fatty acids, conditions often seen in insulin-resistant humans. We had previously shown that adipose Glut4 expression and 5'AMP-activated protein kinase (AMPK) activity increase and plasma glucose decreases in… CONTINUE READING