5' terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart.


Enteroviruses can induce human myocarditis, which can be modeled in mice inoculated with group B coxsackieviruses (CVB) and in which CVB evolve to produce defective, terminally deleted genomes. The 5' non-translated region (NTR) was enzymatically amplified from heart tissue of a fatal case of enterovirus-associated myocarditis in Japan in 2002. While no… (More)
DOI: 10.1016/j.virol.2008.02.030