5'-CpG island promoter hypermethylation of the CAV-1 gene in breast cancer patients of Kashmir.

@article{Syeed20125CpGIP,
  title={5'-CpG island promoter hypermethylation of the CAV-1 gene in breast cancer patients of Kashmir.},
  author={Nidda Syeed and Firdous Hussain and Syed Akhtar Husain and Mushtaq Ahmad Siddiqi},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2012},
  volume={13 1},
  pages={371-5}
}
BACKGROUND Caveolin-1 (CAV-1), encoding the structural component of cellular caveolae, is a suggested tumor suppressor gene involved in cell signalling. Aberrant promoter methylation of CAV-1 is associated with inactivation of expression. We previously observed CAV-1 mutations in breast cancers and therefore devised this study to examine the hypermethylation status of the promoter region of CAV-1 with reference to breast cancer progression and development. METHODS Hypermethylation status of… CONTINUE READING