5‐hydroxymethylfurfural‐ and fluorescein‐fused fluorescence probe of mast cells (RBL‐2H3): Synthesis, photophysical properties, and bioimaging

  title={5‐hydroxymethylfurfural‐ and fluorescein‐fused fluorescence probe of mast cells (RBL‐2H3): Synthesis, photophysical properties, and bioimaging},
  author={Limin Huang and Di Wei and Zibo Wu and Yajing Hou and Yitong Xie and Zhenru Liu and Cheng Wang and Delu Che and Yibo Lei and Huaizhen He},
  journal={Chemical Biology \& Drug Design},
  pages={1963 - 1971}
A fluorescent probe (Fluo‐HMF) was developed via introduction of a furfural moiety into the fluorescein molecular skeleton, aiming at specially labeling cell membrane of mast cells. To illustrate its specificity, we designed and synthesized a series of fluorescent compounds based on fluorescein molecular skeleton. The fluorescent properties of Fluo‐HMF were investigated, which were in accordance with theoretical calculations. Compared with other fluorescein derivatives, Fluo‐HMF could specially… Expand
Medical molecules of waste Chinese buckeye seed from pharmacy
Fourier transform infrared spectroscopy and Gas Chromatography-Mass Spectrometer were used to analyze organic solvent extracts of Populus tomentosa Carriere, the results show that the ChineseExpand


A new far-red naphthorhodamine dye: Synthesis, fluorescent probe and bioimaging applications
Abstract A new extended-π-conjugated naphthorhodamine dye, 9′-diethylamino-2′-hydroxyl-benzo[a]fluoran (1) with a carboxylic acid-functional group was designed and synthesized. Compared to RhodamineExpand
Coumarin- and rhodamine-fused deep red fluorescent dyes: synthesis, photophysical properties, and bioimaging in vitro.
A novel ratiometric sensor (CR1S) for Hg (2+) with good selectivity that could be successfully applied to the imaging of Hg(2+) in living A549 cells is constructed by simply introducing different fluorophores. Expand
Advances in modifying fluorescein and rhodamine fluorophores as fluorescent chemosensors.
The strategies in the development of fluorescent probes that are operating through the modification of the skeletons of fluorescein and rhodamine dyes are overviewed, and the fluorescent behaviors of these probes toward specific analyte are discussed. Expand
4-Nitroimidazole-3-hydroxyflavone conjugate as a fluorescent probe for hypoxic cells
Abstract A novel off-on fluorescent probe for selective detection hypoxia or nitroreductase (NTR),Expand
A sensitive and selective fluorescence probe based fluorescein for detection of hypochlorous acid and its application for biological imaging
Abstract A highly sensitive and selective fluorescein-based probe 1 for hypochlorite anion was synthesized. The probe 1 has favorable characteristics for biological imaging, including high waterExpand
A series of deep red fluorescent dyes: synthesis, theoretical calculations and bioimaging applications
Abstract A series of deep red fluorescent dyes were synthesized and characterized. The optical properties, theoretical calculations, and cytotoxicity of these dyes were investigated. The practicalExpand
FRET-based small-molecule fluorescent probes: rational design and bioimaging applications.
The most recent progress is emphasized on the development of FRET probes by spectral overlap integral, in particular by changing the molar absorption coefficient of the donor dyes such as rhodamine dyes, which undergo unique changes in the absorption profiles during the ring-opening and -closing processes. Expand
The art of fluorescence imaging with chemical sensors.
This Review aims to highlight the state of the art of fluorescence sensing and imaging, starting from a comprehensive overview of the basic functional principles of fluorescent probes (or indicators) and the design of sensor materials. Expand
The RBL-2H3 cell line: its provenance and suitability as a model for the mast cell
It is concluded that while the RBL-2H3 cell line shares some characteristics with both mast cells and basophils, it is not fully representative of either. Expand
Mast cells in allergy and beyond.
There is now compelling evidences that they are important players in innate and acquired immunity, wound healing, fibrosis, tumors and autoimmune diseases, and this review will discuss current advances in these fields. Expand