5‐Methoxy‐N,N‐dimethyltryptamine‐induced analgesia is blocked by α‐adrenoceptor antagonists in rats

@article{Archer19865MethoxyNNdimethyltryptamineinduced,
  title={5‐Methoxy‐N,N‐dimethyltryptamine‐induced analgesia is blocked by $\alpha$‐adrenoceptor antagonists in rats},
  author={Trevor Archer and Wojciech Danysz and G{\"o}sta Jonsson and Bruce G. Minor and Claes Post},
  journal={British Journal of Pharmacology},
  year={1986},
  volume={89}
}
1 The effects of the α‐adrenoceptor antagonists prazosin, phentolamine and yohimbine upon 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeODMT)‐induced analgesia were tested in the hot‐plate, tail‐flick and shock‐titration tests of nociception with rats. 2 Intrathecally injected yohimbine and phentolamine blocked or attenuated the analgesia produced by systemic administration of 5‐MeODMT in all three nociceptive tests. Intrathecally administered prazosin attenuated the analgesic effects of 5‐MeODMT in… Expand
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TLDR
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TLDR
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Intrathecal 5-methoxy-N,N-dimethyltryptamine in mice modulates 5-HT1 and 5-HT3 receptors.
TLDR
The antinociceptive effects of intrathecally administered 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), a potent 5-HT receptor agonist, were studied in three behavioral tests in mice to suggest that it may promote release of 5-hydroxytryptamine, serotonin. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
The analgesic effect of 5-hydroxytryptamine administered into the lumbar intrathecal space of rats was blocked in the tail-flick, hot-plate and shock titration tests of nociception when the animals had previously been treated with DSP4, which depletes noradrenaline in the spinal cord. Expand
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