5‐Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus

@article{Mustafa20085FluorouracilCA,
  title={5‐Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus},
  author={Sarah Mustafa and A. N. Walker and Geoffrey W. Bennett and Peter M. Wigmore},
  journal={European Journal of Neuroscience},
  year={2008},
  volume={28}
}
Chemotherapy‐associated memory deficits in adults are prevalent with systemic treatment utilizing 5‐fluorouracil (5‐Fu). 5‐Fu disrupts cell proliferation and readily crosses the blood–brain barrier. Proliferating cells within the adult dentate gyrus of the hippocampus give rise to new neurons involved in memory and learning and require neurotrophic factors such as brain‐derived neurotrophic factor (BDNF) to nurture this process of adult neurogenesis. Some of these proliferating cells are… 
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The effects of cancer treatments on AHN are discussed and a link between the inhibition of the neurogenetic process in the hippocampus and the advent of the cognitive and mood-based deficits observed in patients and animal models undergoing cancer therapies is proposed.
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