5‐Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety

@article{Dhurat20205AlphaRI,
  title={5‐Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety},
  author={Rachita Dhurat and Aseem Sharma and Lidia Rudnicka and George Kroumpouzos and Martin Kassir and Hassan I Galadari and Uwe Wollina and Torello M Lotti and Ma{\vs}a Golubovi{\'c} and Ivana I Binic and Stephan Grabbe and Mohamad Goldust},
  journal={Dermatologic Therapy},
  year={2020},
  volume={33}
}
Androgenetic alopecia (AGA) is a multifactorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5‐alpha reductase (5‐AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes. Finasteride, which is a single receptor 5‐alpha reductase inhibitor (5‐ARI), acts by blocking dihydrotestosterone (DHT). Dutasteride, a dual receptor DHT… 
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Relative Efficacy of Minoxidil and the 5-α Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients: A Network Meta-analysis.
TLDR
To examine the relative efficacy of any dose and administration route of minoxidil, dutasteride, and finasteride for the treatment of male AGA, a large number of patients with androgenetic alopecia received monotherapy with any of the three interventions.
Finasteride for hair loss: A review.
TLDR
Finasteride is shown to be reasonably tolerated in both men and women; however, patients need to be educated about the possible short- and long-term side-effects.
A Randomized Double-Blind Placebo-Controlled Pilot Trial on the Effects of Testosterone Undecanoate Plus Dutasteride or Placebo on Muscle Strength, Body Composition, and Metabolic Profile in Transmen.
Is COVID-19 a risk factor for progression of benign prostatic hyperplasia and exacerbation of its related symptoms?: a systematic review
TLDR
SARS-CoV-2 can possibly damage the prostate and worsen BPH and its related LUTS through ACE2 signaling, AR-related mechanisms, inflammation, and metabolic derangement.
Scalp and serum profiling of frontal fibrosing alopecia reveals scalp immune and fibrosis dysregulation with no systemic involvement.
Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts
TLDR
C3A is a promising natural compound for AGA treatments against DHT-induced DPC senescence through reduction of MAM formation and mitochondrial dysfunction and the regulatory mechanism involved.
Blue light-emitting diodes in hair regrowth: the first prospective study
TLDR
Blue light therapy is a promising therapy for patients affected by androgenetic alopecia and other diseases characterized by hair loss and further studies will be necessary to confirm the findings.
Photobiomodulation for the management of hair loss
TLDR
Photobiomodulation, otherwise known as low‐level laser (or light) therapy, is an emerging modality for the management of hair loss and comes in many forms including wearable caps or helmets that afford hands‐free and discreet use.
Optimization and Transfollicular Delivery of Finasteride-Loaded Proniosomes for Hair Growth Stimulation in C57BL/6Mlac Mice
TLDR
The results demonstrated that the FLP could stimulate hair growth via a transfollicular delivery system and the efficiency of 1% FLP was comparable to the 2% minoxidil solution.
Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery
TLDR
This optimized formulation of chitosan-based finasteride nanosystem (F5) could increase drug availability in skin and could become a promising carrier for topical delivery to treat androgenic alopecia.
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