5‐α‐Reductase inhibitors for prostate cancer chemoprevention: an updated Cochrane systematic review

@article{Wilt20105ReductaseIF,
  title={5‐$\alpha$‐Reductase inhibitors for prostate cancer chemoprevention: an updated Cochrane systematic review},
  author={Timothy J. Wilt and Roderick MacDonald and Karen L. Hagerty and Paul Schellhammer and James Tacklind and Mark R. Somerfield and Barnett S. Kramer},
  journal={BJU International},
  year={2010},
  volume={106}
}
•  To estimate the benefits and harms of 5‐α‐reductase inhibitors (5‐α‐RIs) in preventing prostate cancer. 
Impact of 5α‐reductase inhibitor and α‐blocker therapy for benign prostatic hyperplasia on prostate cancer incidence and mortality
To investigate the use of 5α‐reductase inhibitors (5ARIs) and α‐blockers among men with benign prostatic hyperplasia (BPH) in relation to prostate cancer (PCa) incidence, severity and mortality.
The impact of 5-alpha-reductase inhibitors on mortality in a prostate cancer chemoprevention setting: a meta-analysis
TLDR
5ARI significantly reduced the risk of being diagnosed with PCa, not increasing high-grade disease, overall or cancer-specific mortality, and the incidence of PCa diagnosis and disease aggressiveness.
Therapy‐associated effects in the prostate gland
Srigley J R, Delahunt B & Evans A J 
(2012) Histopathology 60, 153–165
Risk adapted chemoprevention for prostate cancer: an option?
TLDR
The authors conclude that chemoprevention in a high risk cohort using 5-α reductase inhibitors is a viable option and may even be cost effective and should be further explored in an open and unbiased way.
Endocrine prevention and treatment of prostate cancer
  • T. Tammela
  • Medicine, Biology
    Molecular and Cellular Endocrinology
  • 2012
Prostate Cancer Chemoprevention Study: An investigative randomized control study using purified isoflavones in men with rising prostate‐specific antigen
TLDR
The value of is oflavone for prostate cancer risk reduction is supported, and a large‐scale phase III randomized study of isoflavone tablets in men with different hereditary factors and living environments is warranted.
A Perspective on Prostate Carcinogenesis and Chemoprevention
TLDR
Prostate cancer is a slowly developing cancer which offers opportunities for preventive interventions, but there are no known dietary or life style interventions that will have a major impact on prostate cancer risk.
Primary cancers before and after prostate cancer diagnosis
The occurrence of multiple cancers may indicate common etiology; and, although some studies have investigated the risk of second primary cancers after prostate cancer (PCa), there are no studies on
Primary prevention and early diagnosis of prostate cancer: recommendations from the prevention and early diagnosis working group of the Spanish Society of Medical Oncology (SEOM)
  • Á. Pinto, P. Pérez Segura
  • Medicine
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
  • 2016
TLDR
The available evidence is reviewed and some general recommendations for prostate cancer primary prevention and screening are suggested.
...
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References

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Five-alpha-reductase inhibitors reduce prostate cancer risk but may increase the risk of high-grade disease in men who are undergoing regular screening for prostate cancer using prostate specific antigen and digital rectal examination.
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TLDR
The sensitivity of PSA was higher for men in the finasteride group than in the placebo group at all PSA cutoffs matched by specificity, and this bias would be expected to contribute to greater detection of all grades of prostate cancer withfinasteride.
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