5α-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain

@article{Pathirathna20055reducedNS,
  title={5α-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain},
  author={Sriyani Pathirathna and Slobodan M Todorovic and Douglas F Covey and Vesna Jevtovi{\'c}-Todorovi{\'c}},
  journal={Pain},
  year={2005},
  volume={117},
  pages={326-339}
}
5alpha-reduced neuroactive steroids with selective modulatory action in vitro on T or combined modulatory action on T and GABA(A) currents present in peripheral sensory neurons have been shown to induce potent peripheral analgesia in vivo in intact animals. Although the role of T and GABA(A) currents in pathophysiology of neuropathic pain (NPP) is not established, it appears that blockade of T currents and/or potentiation of GABA(A) currents could be beneficial in the management of NPP. To… CONTINUE READING

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