5α-Reductase Activity in Women with Polycystic Ovary Syndrome1

@inproceedings{Jakimiuk19995ReductaseAI,
  title={5α-Reductase Activity in Women with Polycystic Ovary Syndrome1},
  author={Artur J. Jakimiuk and Stacy R. Weitsman and Denis A. Magoffin},
  year={1999}
}
The recent demonstration of high concentrations of 5α-androstane-3,17-dione in the follicular fluid of polycystic ovaries suggests a potential role for 5α-reduced androgens in the etiology of polycystic ovary syndrome (PCOS). The purpose of the present study was to determine whether there is increased 5α-reductase activity or messenger ribonucleic acid (mRNA) expression in polycystic ovaries. 5α-Reductase 1 and 5α-reductase 2 mRNAs were measured in thecal (TC) and granulosa (GC) cells from… CONTINUE READING

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