5,7-Dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6-hydroxydopamine-lesioned rats

@article{Liu200757DihydroxytryptamineLO,
  title={5,7-Dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6-hydroxydopamine-lesioned rats},
  author={Jian Liu and Yu-Xia Chu and Qiao Jun Zhang and Shuang Wang and Jie Feng and Qiang Li},
  journal={Brain Research},
  year={2007},
  volume={1149},
  pages={216-222}
}
Modulation of the subthalamic nucleus activity by serotonergic agents and fluoxetine administration
TLDR
The results indicate that the depletion and the blockage of 5-HT modify STN neuron firing pattern, which may explain the role of this nucleus in fluoxetine-induced extrapyramidal side effects.
Local administration of sarizotan into the subthalamic nucleus attenuates levodopa-induced dyskinesias in 6-OHDA-lesioned rats
TLDR
Results suggest that the STN is a target structure for the antidyskinetic action of sarizotan and indicate that drug-mediated modulation of STN activity may be an alternative option for the treatment of levodopa-induced dyskinesias in Parkinson’s disease.
Interaction between the 5-HT system and the basal ganglia: functional implication and therapeutic perspective in Parkinson's disease
TLDR
An overview of serotonergic modulation of the BG at the functional level is provided and a discussion of how this interaction may be relevant to treating PD and the motor complications induced by chronic treatment with L-DOPA is discussed.
Serotonin regulation of subthalamic neurons
TLDR
5-HT may affect glutamate release at the intra-STN axon collaterals and regulate the recurrent excitation and fine-tune the intensity and pattern of STN activity and reduce STN output bursts.
Characterization of Induced Pluripotent Stem Cell-derived Human Serotonergic Neurons
TLDR
It is found that these human serotonergic neurons are sensitive to the selective neurotoxin 5, 7-Dihydroxytryptamine (5,7-DHT) in vitro and in vivo and after being transplanted into newborn mice, the cells not only expressed their typical molecular markers, but also showed the migration and projection to the host’s cerebellum, hindbrain and spinal cord.
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TLDR
It is demonstrated that PPN neurons are overactive and more irregular in the 6‐hydroxydopamine‐lesioned rats, suggesting the implication of this nucleus in the pathophysiology of parkinsonism.
Effect of microiontophoretic application of dopamine on subthalamic nucleus neuronal activity in normal rats and in rats with unilateral lesion of the nigrostriatal pathway
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It is shown that dopamine exerts an excitatory influence on STN neurons, suggesting that the inhibitory effect induced by the systemic injection of apomorphine is due to the GABAergic inputs from the globus pallidus as predicted by the current model of basal ganglia organization.
Intrasubthalamic injection of 6‐hydroxydopamine induces changes in the firing rate and pattern of subthalamic nucleus neurons in the rat
TLDR
It is suggested that the SNc exerts an excitatory influence on STN neurons and that the loss of this dopaminergic projection could, at least partially, account for the changes in the firing pattern of STn neurons in the 6‐OHDA rat model of parkinsonism.
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TLDR
The effects of electrical stimulation of the DRN on the spontaneous activity of substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) DA neurons in anesthetized rats are investigated and it is suggested that non‐5‐HT inputs from DR can also modulate mesencephalic DA neurons.
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TLDR
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Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies
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Results show that subthalamic nucleus lesion provides neuroprotection of the dopaminergic nigrostriatal pathway against 6‐OHDA toxicity and opens a new way for slowing or stopping the progression of Parkinson's disease.
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