5,10-Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms: genotype frequency and association with homocysteine and folate levels in middle-southern Italian adults.

@article{Zappacosta2014510MethylenetetrahydrofolateR,
  title={5,10-Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms: genotype frequency and association with homocysteine and folate levels in middle-southern Italian adults.},
  author={Bruno Zappacosta and Mirella Graziano and Silvia Persichilli and Augusto F Di Castelnuovo and Pierpaolo Mastroiacovo and Licia Iacoviello},
  journal={Cell biochemistry and function},
  year={2014},
  volume={32 1},
  pages={1-4}
}
Two genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene (C677T and A1298C) can influence the plasma homocysteine (Hcy) levels, especially in the presence of an inadequate folate status. The aim of this study was to evaluate the frequencies of C677T and of A1298C MTHFR polymorphisms and their correlation with Hcy and serum folate concentrations in a population of blood donors living in a region of middle-southern Italy (the Molise Region). One hundred ninety seven blood… CONTINUE READING