5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy.

  title={5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy.},
  author={Danos C. Christodoulou and Hiroko Wakimoto and K Onoue and Seda Eminaga and Joshua M. Gorham and Steve Depalma and Daniel S. Herman and Polakit Teekakirikul and David A. Conner and David M. McKean and Andrea A. Domenighetti and Anton Aboukhalil and Stephen H Chang and Gyan Srivastava and Barbara McDonough and Philip L De Jager and Ju Chen and Martha L. Bulyk and Jochen Daniel Muehlschlegel and Christine E Seidman and Jonathan G Seidman},
  journal={The Journal of clinical investigation},
  volume={124 3},
The transcriptome is subject to multiple changes during pathogenesis, including the use of alternate 5' start-sites that can affect transcription levels and output. Current RNA sequencing techniques can assess mRNA levels, but do not robustly detect changes in 5' start-site use. Here, we developed a transcriptome sequencing strategy that detects genome-wide changes in start-site usage (5'RNA-Seq) and applied this methodology to identify regulatory events that occur in hypertrophic… CONTINUE READING


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