5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I.

@article{Schmidt20095triphosphateRR,
  title={5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I.},
  author={Andreas Schmidt and Tobias Schwerd and Wolfgang Hamm and Johannes C. Hellmuth and Sheng Cui and Michael Wenzel and Franziska S. Hoffmann and M Michallet and Robert Besch and Karl-Peter Hopfner and S. Endres and Simon Rothenfusser},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 29},
  pages={12067-72}
}
The ATPase retinoid acid-inducible gene (RIG)-I senses viral RNA in the cytoplasm of infected cells and subsequently activates cellular antiviral defense mechanisms. RIG-I recognizes molecular structures that discriminate viral from host RNA. Here, we show that RIG-I ligands require base-paired structures in conjunction with a free 5'-triphosphate to trigger antiviral signaling. Hitherto unavailable chemically synthesized 5'-triphosphate RNA ligands do not trigger RIG-I-dependent IFN production… CONTINUE READING

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