5'-Terminal nucleotide sequence of Escherichia coli lactose repressor mRNA: features of translational initiation and reinitiation sites.

@article{Steege19775TerminalNS,
  title={5'-Terminal nucleotide sequence of Escherichia coli lactose repressor mRNA: features of translational initiation and reinitiation sites.},
  author={D. A. Steege},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1977},
  volume={74 10},
  pages={4163-7}
}
  • D. A. Steege
  • Published 1977 in
    Proceedings of the National Academy of Sciences…
In a sequence of 214 nucleotides at the 5' terminus of the I gene mRNA, which codes for the lactose repressor protein of Escherichia coli, (i) an untranslated leader sequence of 28 residues precedes the repressor coding region; (ii) a GUG initiates synthesis of the wild-type repressor; (iii) GUG and AUG are the functional initiators for the synthesis of restart polypeptides activated by early I gene amber mutations, confirming previous assignments for these residues based on protein sequencing… CONTINUE READING

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