5'-Nucleotidase from Vipera lebetina venom.

@article{Trummal20155NucleotidaseFV,
  title={5'-Nucleotidase from Vipera lebetina venom.},
  author={Katrin Trummal and Mari Samel and Anu Aasp{\~o}llu and K{\"u}lli T{\~o}nism{\"a}gi and T Titma and Juhan Subbi and J{\"u}ri Siigur and Ene Siigur},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2015},
  volume={93},
  pages={155-63}
}
5'-Nucleotidase (5'-NT) is widely represented in animal tissues (CD73) as well as in almost all snake venoms. In the present study, a 5'-NT isoform has been isolated from Vipera lebetina venom. The homodimeric isoform consists of monomers with molecular masses of 60 kDa. The enzyme is thermolabile and has pH optimum at 7.5. The 5'-NT activity is inhibited by metal ions Fe(3+), Cu(2+) and Zn(2+), enhanced by Mn(2+) while Mg(2+) and Ca(2+) have no remarkable effect. In addition to 120-kDa protein… CONTINUE READING
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