5'-Diphosphoadenosine 3'-phosphate is a potent inhibitor of bovine pancreatic ribonuclease A.

@article{Russo19975Diphosphoadenosine3I,
  title={5'-Diphosphoadenosine 3'-phosphate is a potent inhibitor of bovine pancreatic ribonuclease A.},
  author={Nicola Russo and Robert P Shapiro and Bert L. Vallee},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={231 3},
  pages={671-4}
}
As a first step toward the development of stable, selective, and potent inhibitors of those members of the pancreatic RNase superfamily that induce biological responses, we have focussed on low molecular weight compounds and studied their interactions with the active-site of bovine pancreatic ribonuclease A (RNase A). A new inhibitor is described, 5'-diphosphoadenosine 3'-phosphate, which binds to RNase A more tightly than any previous low molecular weight compound: its Ki value of 1.3 microM… CONTINUE READING

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