5&agr;-Reductase inhibitors in androgenetic alopecia

  title={5\&agr;-Reductase inhibitors in androgenetic alopecia},
  author={Elizabeth Yim and Katherine L Baquerizo Nole and Antonella Tosti},
  journal={Current Opinion in Endocrinology \& Diabetes and Obesity},
Purpose of reviewThe authors will review the current literature on efficacy and safety of 5-alpha reductase inhibitors (5&agr;RIs) for androgenetic alopecia (AGA). Recent findingsThe 5&agr;RI finasteride and dutasteride are effective in treating AGA and promoting hair regrowth. 5&agr;RI can be given orally, topically and more recently through mesotherapy. However, there has been an increasing concern about permanent sexual adverse events such as impotence and infertility. Most of these reports… 
Safety concerns when using novel medications to treat alopecia
This review summarizes the safety concerns when using novel therapeutic modalities such as JAK inhibitors, hair transplantation, mesotherapy, oral minoxidil, platelet-rich plasma, microneedling, and 5α-reductase inhibitors for treating hair loss.
The Impact of the 5α-Reductase Inhibitors (5α-RIs) on Male Sexual Function and Psychological Well-Being
  • A. Traish
  • Medicine, Psychology
    Current Sexual Health Reports
  • 2015
It is imperative that clinicians give serious considerations to these adverse effects and their impact on patients’ health and engage their patients in an open and honest discussion regarding the potential harm of these agents prior to prescribing them.
Finasteride adverse effects and post-finasteride syndrome; implications for dentists
This study intends to present in this study several oral adverse effects encountered during finasteride administration, represented by mild and moderate signs which generally responded to topical procedures without to require the stop of the drug administration.
Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-analysis.
It is concluded that finasteride treatment of androgenic alopecia (AGA) is safe but do not assess quality of safety reporting, and published reports of clinical trials provide insufficient information to establish the safety profile forfinasteride in the treatment of AGA.
Androgenetic Alopecia Treatment in Asian Men.
A combination of these therapeutic options offers safe and highly efficacious treatment for AGA with minimal complications and significant improvement was observed in all patients in the digital photographs.
Impact of Finasteride Administration on Neuroactive Steroid Levels To Induce Persistent Sexual Side Effects and Anxious / Depressive Disorders and the Possible Protective Effect of Vitamin E
Evaluating the changes of neuroactive steroid ALLO Level in Finasteride treated rats and its relation to induce persistent sexual side effects and anxious/depressive symptoms found that cognition and sexuality are two distinct but interrelated environmental functions, most probable due to lateralization process of the brain.
Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know?
The state of art on this topic is summarized, the key unresolved questions that have emerged on the pharmacological targeting of these enzymes and their products are overview, and the need for further studies to ascertain the severity and duration of the adverse effects of 5α-R inhibitors, as well as their biological underpinnings is highlighted.
Physcion, a novel inhibitor of 5α-reductase that promotes hair growth in vitro and in vivo
Through inhibiting 5α-reductase expression, Physcion could shorten the time of dorsal skin darkening and hair growth, improve hair follicle morphology, and significantly increase hair follicles count.
Treatments options for alopecia
This paper aims to provide an overview of available treatments for the most common forms of alopecia in adults (androgenetic alopECia [AGA], alopicia areata and cicatricialAlopecias) after reviewing the literature in PubMed, Google Scholar and ClinicalTrial.gov.
Bee Venom Promotes Hair Growth in Association with Inhibiting 5α-Reductase Expression.
Bee venom is a potentially potent 5α-reductase inhibitor and hair growth promoter and this study investigated the preventive effect of bee venom on alopecia.


Topical finasteride in the treatment of androgenic alopecia. Preliminary evaluations after a 16-month therapy course
The clinical outcome, in terms of both hair regrowth and balding areas reduction, seems to be encouraging, in the absence of either any evidence of percutaneous absorption of finasteride, or local/systemic untoward effects.
Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients.
INTRODUCTION 5α-reductase inhibitors (5α-RIs), finasteride and dutasteride, have been approved for treatment of lower urinary tract symptoms, due to benign prostatic hyperplasia, with marked clinical
Efficacy and safety of finasteride therapy for androgenetic alopecia: a systematic review.
Moderate-quality evidence suggests that daily use of oral finasteride increases hair count and improves patient and investigator assessment of hair appearance, while increasing the risk of sexual dysfunction.
The efficacy and safety of 5α-reductase inhibitors in androgenetic alopecia: a network meta-analysis and benefit–risk assessment of finasteride and dutasteride
Analysis results reiterate the efficacy and safety of 5α-reductase inhibitors for the treatment of AGA and may support the approval of dutasteride 0.5 mg as an additional treatment option, following further study.
Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia.
In postmenopausal women with AGA, finasteride 1 mg/day taken for 12 months did not not increase hair growth or slow the progression of hair thinning.
Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men
It is inferred that the therapeutic efficacy is enhanced by combining the two drugs acting on different aetiological aspects of AGA by combining finasteride alone or in combination with minoxidil or ketoconazole.
Finasteride, 1 mg daily administration on male androgenetic alopecia in different age groups: 10‐year follow‐up
Its efficacy was not reduced as time goes on; in fact, a big proportion of subjects unchanged after 1 year, improved later on, maintaining a positive trend.
Depression Circumstantially Related to the Administration of Finasteride for Androgenetic Alopecia
Depression, which significatively impaired sociofamilial relations, sleep and eating behaviour, was associated to marked anxiety in some cases, developed after 9–19 weeks of treatment with finasteride, and promptly resolved after suspension of the drug.
Efficacy of Finasteride for Treating Patients with Androgenetic Alopecia who are Pileous in other Areas: A Pilot Study in Japan
  • T. Inadomi
  • Medicine
    Indian journal of dermatology
  • 2014
Investigating the effects of finasteride on hair, including the head and other areas of the body, suggests that about half of Androgenetic alopecia patients in Japan are pileous in other parts of theBody.
An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia
Both drugs were effective and safe in the treatment of mild to severe AGA, although oral finasteride treatment was more effective (p < 0.05); side effects were all mild, and there was no need to stop the treatment.