4IgB7-H3 is the major isoform expressed on immunocytes as well as malignant cells.

@article{Zhou20074IgB7H3IT,
  title={4IgB7-H3 is the major isoform expressed on immunocytes as well as malignant cells.},
  author={Yi-Hua Zhou and Y Chen and Z Ma and L Y Xu and Qin Wang and G-B Zhang and Fang Xie and Yaping Ge and Xin Wang and Xiaohui Zhang},
  journal={Tissue antigens},
  year={2007},
  volume={70 2},
  pages={96-104}
}
Human B7-H3, a novel member of B7 family, has two isoforms (2IgB7-H3 and 4IgB7-H3). As costimulatory functions of both isoforms are not clarified, there has been much discussion on their expression patterns, T-cell responses, etc. This study generated two specific mouse anti-human 2IgB7-H3 monoclonal antibodies (mAbs) (7D7 and 10F1), whose specificities are quite different from those of the available B7-H3 mAb (21D4) by competition assay. The use of antibodies indicated that B7-H3 was found to… CONTINUE READING

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