4F, apolipoprotein AI mimetic peptide, attenuates acute lung injury and improves survival in endotoxemic rats.

@article{Kwon20124FAA,
  title={4F, apolipoprotein AI mimetic peptide, attenuates acute lung injury and improves survival in endotoxemic rats.},
  author={Woon Yong Kwon and Gil Joon Suh and Kyung Su Kim and Young Ho Kwak and Kyuseok Kim},
  journal={The journal of trauma and acute care surgery},
  year={2012},
  volume={72 6},
  pages={1576-83}
}
BACKGROUND 4F, apolipoprotein AI mimetic peptide, mimics anti-inflammatory properties of high-density lipoprotein (HDL). The aim of this study was to investigate whether 4F attenuates acute lung injury and improves survival in endotoxemic rats and to determine whether the therapeutic benefits of 4F are associated with the stimulation of sphingosine-1-phosphate receptor 1 (S1P1), the activation of Akt, the down-regulation of the nuclear factor-κB (NF-κB) pathway, and the suppression of cell… CONTINUE READING

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