4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.

@article{Wang20154EBP1eIF4EAP,
  title={4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.},
  author={Chunmei Wang and Antonio Cigliano and Lijie Jiang and Xiaolei Li and Biao Fan and Maria Pilo and Yan Liu and Bing Gui and Marcella Sini and Jeffrey W. Smith and Frank Dombrowski and Diego F Calvisi and Matthias Evert and Xin Jane Chen},
  journal={Hepatology},
  year={2015},
  volume={61 1},
  pages={200-13}
}
UNLABELLED Concomitant expression of activated forms of v-akt murine thymoma viral oncogene homolog (AKT) and Ras in mouse liver (AKT/Ras) leads to rapid tumor development through strong activation of the mammalian target of rapamycin complex 1 (mTORC1) pathway. mTORC1 functions by regulating p70S6K/ribosomal protein S6 (RPS6) and eukaryotic translation initiation factor 4E-binding protein 1/ eukaryotic translation initiation factor 4E (4EBP1/eIF4E) cascades. How these cascades contribute to… CONTINUE READING
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