Corpus ID: 195833404

4D Liquid-phase Electron Microscopy of Ferritin by Brownian Single Particle Analysis

  title={4D Liquid-phase Electron Microscopy of Ferritin by Brownian Single Particle Analysis},
  author={Gabriele Marchello and Cesare De Pace and N. Wilkinson and L. Ruiz-P{\'e}rez and G. Battaglia},
  journal={arXiv: Biomolecules},
  • Gabriele Marchello, Cesare De Pace, +2 authors G. Battaglia
  • Published 2019
  • Chemistry, Biology, Physics
  • arXiv: Biomolecules
  • Protein function and activity are a consequence of its three-dimensional structure. Single particle analysis of cryogenic electron micrographs has radically changed structural biology allowing atomic reconstruction of almost any type of proteins. While such an approach provides snapshots of three-dimensional structural information that can be correlated with function, the new frontier of protein structural biology is in the fourth dimension, time. Here we propose the use of liquid phase… CONTINUE READING
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